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Meta-Analysis
. 2009 Aug;2(4):322-8.
doi: 10.1161/CIRCGENETICS.108.833806. Epub 2009 May 15.

A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project

Fabio Marroni  1 , Arne Pfeufer, Yurii S Aulchenko, Christopher S Franklin, Aaron Isaacs, Irene Pichler, Sarah H Wild, Ben A Oostra, Alan F Wright, Harry Campbell, Jacqueline C Witteman, Stefan Kääb, Andrew A Hicks, Ulf Gyllensten, Igor Rudan, Thomas Meitinger, Cristian Pattaro, Cornelia M van Duijn, James F Wilson, Peter P Pramstaller; EUROSPAN Consortium
Affiliations
Meta-Analysis

A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project

Fabio Marroni et al. Circ Cardiovasc Genet. 2009 Aug.

Abstract

Background: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations.

Methods and results: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval.

Conclusions: Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.

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Figures

Figure 1
Figure 1
Results of association between RR interval and SNPs in the GPR133 gene.
Figure 2
Figure 2
Results of association between QT interval and SNPs in the NOS1AP gene.
See this image and copyright information in PMC

References

    1. Dyer AR, Persky V, Stamler J, Paul O, Shekelle RB, Berkson DM, Lepper M, Schoenberger JA, Lindberg HA. Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies. Am J Epidemiol. 1980;112:736–749. - PubMed
    1. Fox K, Borer JS, Camm AJ, Danchin N, Ferrari R, Lopez Sendon JL, Steg PG, Tardif JC, Tavazzi L, Tendera M. Heart Rate Working Group. Resting heart rate in cardiovascular disease. J Am Coll Cardiol. 2007;50:823–830. - PubMed
    1. Kristal-Boneh E, Silber H, Harari G, Froom P. The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study) Eur Heart J. 2000;21:116–124. - PubMed
    1. Singh JP, Larson MG, O’Donnell CJ, Tsuji H, Evans JC, Levy D. Heritability of heart rate variability: the Framingham Heart Study. Circulation. 1999;99:2251–2254. - PubMed
    1. Laramie JM, Wilk JB, Hunt SC, Ellison RC, Chakravarti A, Boerwinkle E, Myers RH. Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program. BMC Med Genet. 2006;7:17. - PMC - PubMed

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