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Review
. 2009 Dec;2(6):637-51.
doi: 10.1161/CIRCGENETICS.109.891366.

Nutrigenomics in cardiovascular medicine

Dolores Corella  1 , Jose M Ordovas
Affiliations
Review

Nutrigenomics in cardiovascular medicine

Dolores Corella et al. Circ Cardiovasc Genet. 2009 Dec.
No abstract available

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Figures

Figure 1
Figure 1. Types of statistically significant gene-diet interactions
Figure 1A. Statistically significant gene-diet interaction in which the genotypic effects are statistically significant in the whole population. Main genetic effects (A1), gene-diet interaction as categorical (A2) and as continuous (A3). P1 and P2 indicate the P values for mean comparison of the phenotypical trait (Plasma Y concentrations as example) depending on the genotype (A>G variation as example) in each of the dietary strata (diet 1 and diet 2) for the categorical variable. The gene-diet interaction makes that association between the genotype and phenotype stronger in one of the dietary intake strata, and weaker in the other. In the second situation (Figure 1B), no genetic effect is observed in the whole population (B1). Presence of the gene-diet interaction was depicted as categorical (B2) and as continuous (B3). The SNP is not significantly associated with the phenotype, but if it is stratified by the diet component the inverse genetic effect in each of dietary strata can be statistically observed.
Figure 2
Figure 2. Genetic determinism and biological gene-diet interactions
A phenotypical trait (plasma Y concentrations) depending on the genotype (normal vs mutant allele) and diet (from dieti and dietn) according to: Genetic determinism (A), a biological but not statistically significant gene-diet interaction (B), and two common biological and statistically significant gene-diet interactions (C). P values for the interaction terms between genotype and diet as well as P values (Pd) for mean differences of the Y parameter in subjects carrying the mutant allele depending on the diet (Dieti and Dietn) are shown. Pathological levels of plasma Y concentrations are also indicated.
Figure 3
Figure 3. Example of a biological, non-statistically significant, gene-diet interaction
Plasma HDL-C concentrations depending on the CETP-TaqIB SNP and alcohol intake (3 categories: no alcohol intake, moderate, and high intake). No statistically significant gene-diet interaction is found (P for interaction between the CETP-TaqIB polymorphisms and alcohol consumption=0.750) (A). B: HDL-C concentrations in B1B1 subjects in the stratum of high alcohol consumption and HDL-C concentrations in B2B2 subjects in the stratum of no alcohol intake. P value for the comparison of means between B1B1 and B2B2 subjects.
Figure 3
Figure 3. Example of a biological, non-statistically significant, gene-diet interaction
Plasma HDL-C concentrations depending on the CETP-TaqIB SNP and alcohol intake (3 categories: no alcohol intake, moderate, and high intake). No statistically significant gene-diet interaction is found (P for interaction between the CETP-TaqIB polymorphisms and alcohol consumption=0.750) (A). B: HDL-C concentrations in B1B1 subjects in the stratum of high alcohol consumption and HDL-C concentrations in B2B2 subjects in the stratum of no alcohol intake. P value for the comparison of means between B1B1 and B2B2 subjects.
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