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. 2010 Jun;54(2):191-6.
doi: 10.1097/QAI.0b013e3181c99226.

Hepatitis B and hepatitis C seroprevalence in children receiving antiretroviral therapy for human immunodeficiency virus-1 infection in China, 2005-2009

Shuntai Zhou  1 , Yan Zhao, Yun He, Huiqin Li, Marc Bulterys, Xin Sun, Zhihui Dou, Matthew Robinson, Fujie Zhang
Affiliations

Hepatitis B and hepatitis C seroprevalence in children receiving antiretroviral therapy for human immunodeficiency virus-1 infection in China, 2005-2009

Shuntai Zhou et al. J Acquir Immune Defic Syndr. 2010 Jun.

Abstract

Background: Coinfection of hepatitis B virus (HBV) or hepatitis C virus (HCV) may compromise pediatric antiretroviral therapy (ART) in China. In this study, we evaluated the seroprevalence of HBV and HCV in children receiving ART and associated factors.

Methods: Patients were selected from HIV-1-infected children under age 16 enrolled in China National Pediatric ART Cohort since July 2005. Medical assessments, hepatitis B surface antigen (HBsAg), and anti-HCV antibody serologies, and transaminase levels were obtained for analysis.

Results: A total of 53 of 1082 children tested were HBsAg seropositive [4.9%; 95% confidence interval (CI): 3.6% to 6.2%], and 90 of 938 children tested were anti-HCV antibody positive (9.6%; 95% CI: 7.7% to 11.5%). No other serologic assays were performed for HBV detection. Age was associated with HBV coinfection in univariate analysis; older children were more likely to be HBsAg positive. Multivariate analysis revealed that children infected with HIV through transfusion of contaminated blood or blood products were more likely to be anti-HCV antibody positive than those infected with HIV through other routes (adjusted odds ratio = 6.2; 95% CI: 3.3% to 11.7%).

Conclusions: The high prevalence of HBV and HCV coinfection in HIV-infected children in China receiving ART demands routine screening for viral hepatitis coinfection, intensive prevention of childhood HBV and HCV transmission, and modification of the management of pediatric HIV infection.

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Figures

Figure 1
Figure 1
describes HBsAg seropositivity rate (%) overall and divided by age group, HIV transmission route and residency in central Chinese provinces.
Figure 2
Figure 2
describes anti-HCV seropositivity rate (%) overall and divided by age group, HIV transmission route and residency in central Chinese provinces.
See this image and copyright information in PMC

References

    1. National AIDS prevention and treatment data information seasonal report. Beijing, China: National Center for AIDS/STD Control and Prevention, China CDC; 2008. Sept, pp. 1–2.
    1. A Joint Assessment of HIV/AIDS Prevention, Treatment and Care in China (2007) Beijing: State Council AIDS Working Committee Office, UN Theme Group on AIDS in China; 2007. Dec 1,
    1. Zhang F, Au MC, Bouey PD, et al. The diagnosis and treatment of HIV-infected children in China: challenges and opportunities. J Acquir Immune Defic Syndr. 2007 Apr 1;44(4):429–434. - PubMed
    1. Zhang F, Haberer JE, Zhao Y, et al. Chinese pediatric highly active antiretroviral therapy observational cohort: a 1-year analysis of clinical, immunologic, and virologic outcomes. J Acquir Immune Defic Syndr. 2007 Dec 15;46(5):594–598. - PubMed
    1. Williams R. Global challenges in liver disease. Hepatology. 2006 Sep;44(3):521–526. - PubMed

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