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. 2009 Nov 26;14(12):4858-65.
doi: 10.3390/molecules14124858.

A facile synthesis of 2,4-disubstituted thiazoles using MnO2

Yan-Bo Yu  1 , Hong-Liang Chen, Li-Yi Wang, Xin-Zheng Chen, Bin Fu
Affiliations

A facile synthesis of 2,4-disubstituted thiazoles using MnO2

Yan-Bo Yu et al. Molecules. .

Abstract

Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO(2)) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.

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Figures

Scheme 1
Scheme 1
The synthesis of 2,4-disubstituted thiazoles.
Scheme 2
Scheme 2
The synthesis of 2,4-disubstituted bis-thiazoles.
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