Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Dec 8;14(12):5103-14.
doi: 10.3390/molecules14125103.

Antimalarial activity of ultra-short peptides

Lemuel Pérez-Picaso  1 , Benjamín Velasco-Bejarano, A Berenice Aguilar-Guadarrama, Rocío Argotte-Ramos, María Yolanda Rios
Affiliations

Antimalarial activity of ultra-short peptides

Lemuel Pérez-Picaso et al. Molecules. .

Abstract

Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC(50) data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC(50) values of 3.31 and 2.57 microM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.

PubMed Disclaimer

References

    1. Alba M.P., Salazar L.M., Puentes A., Pinto M., Torres E., Patarroyo M.E. 6746 SERA peptide analogues immunogenicity and protective efficacy against malaria is associated with short helix formation: Malaria protection associated with peptides helix shortening. Peptides. 2003;24:999–1006. doi: 10.1016/S0196-9781(03)00187-6. - DOI - PubMed
    1. Greenwood B., Mutabingwa T. Malaria in 2002. Nature. 2002;415:670–672. doi: 10.1038/415670a. - DOI - PubMed
    1. Eda K., Eda S., Sherman I.W. Identification of peptides targeting the surface of Plasmodium falciparum-infected erythrocytes using a phage display peptide library. Am. J. Trop. Med. Hyg. 2004;71:190–195. doi: 10.4269/ajtmh.2004.71.190. - DOI - PubMed
    1. Cunha-Rodrigues M., Prudencio M., Mota M.M., Haas W. Antimalarial drugs-host targets (re)visited. Biotech. J. 2006;1:321–332. doi: 10.1002/biot.200500038. - DOI - PubMed
    1. Snow R.W., Guerra C.A., Noor A.M., Myint H.Y., Hay S.I. The global distribution of clinical episodes of plasmodium falciparum malaria. Nature. 2005;434:214–217. doi: 10.1038/nature03342. - DOI - PMC - PubMed

Publication types

LinkOut - more resources