Case Reports
doi: 10.1002/1097-0142(197711)40:5<2171::aid-cncr2820400527>3.0.co;2-f.
Bronchiolo-alveolar carcinoma: a Clara cell tumor?
- PMID: 200334
- DOI: 10.1002/1097-0142(197711)40:5<2171::aid-cncr2820400527>3.0.co;2-f
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Case Reports
Bronchiolo-alveolar carcinoma: a Clara cell tumor?
Cancer.
1977 Nov.
Abstract
The cell of origin, and indeed the very existence, of bronchiolo-alveolar carcinoma have long been the subject of debate. Published cases have demonstrated the presence of type II pneumocytes in some tumors, while others have been composed of mucus-secreting bronchiolar cells. A case of bronchiolo-alveolar carcinoma is presented in which the ultrastructure indicates an origin from Clara cells, but in which some cells contain polymorphous and lamellar bodies, It is concluded that bronchiolo-alveolar carcinoma is a primary lung tumor derived from the terminal airways and in the majority of cases from the bronchiole. The value of electron microscopy in assessing such tumors is emphasized.
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