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. 1966 Dec;4(3):189-98.
doi: 10.1016/0022-3956(66)90006-9.

Brain amines and emotional stress

E L Bliss  1 , J Zwanziger
Affiliations

Brain amines and emotional stress

E L Bliss et al. J Psychiatr Res. 1966 Dec.

Abstract

Evidence is presented that emotional stress in the mouse, guinea pig, and rat are associated with 10-30 per cent decrements in brain norepinephrine. This does not appear to be primarily a function of muscular activity and is probably a neurochemical concomitant of the 'emotional' upset. It is a generalized phenomenon that occurs in cortex, subcortex, cerebellum, hypothalamus, and brain stem, to approximately the same degree. Under these circumstances the concentration in brain of serotonin, gamma-aminobutyric acid, and dopamine remain stable. It appears that decreases of brain norepinephrine may be a component of a general response to intense, emotional distress.

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