Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Dec 24:2:21.
doi: 10.1186/1757-2215-2-21.

Mucins in ovarian cancer diagnosis and therapy

Subhash C Chauhan  1 , Deepak Kumar, Meena Jaggi
Affiliations

Mucins in ovarian cancer diagnosis and therapy

Subhash C Chauhan et al. J Ovarian Res. .

Abstract

Ovarian cancer is the most lethal gynecologic malignancy and the five-year survival rate is only 35% after diagnosis. Epithelial ovarian cancer is a highly metastatic disease characterized by widespread peritoneal dissemination and ascites. The death incidences from ovarian cancer could be significantly lowered by developing new methods for the early diagnosis and treatment of this fatal disease. Several potential markers have been identified recently. However, mucins are the most promising markers for ovarian cancer diagnosis. Mucins are large extracellular, heavily glycosylated proteins and their aberrant expression has been implicated in the pathogenesis of a variety of cancers, including ovarian cancer. This review will summarize known facts about the pathological and molecular characteristics of ovarian cancer, the current status of ovarian cancer markers, as well as general information about mucins, the putative role of mucins in the progression of ovarian cancer and their potential use for the early diagnosis and treatment of this disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Expression of MUC1 (A), MUC13 (B) and MUC16/CA125 (C) trans-membrane mucins in ovarian tumors.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Alexander-Sefre F, Menon U, Jacobs IJ. Ovarian cancer screening. Hosp Med. 2002;63:210–213. - PubMed
    1. Ozols RF. Update on the management of ovarian cancer. Cancer J. 2002;8(Suppl 1):S22–30. - PubMed
    1. Auersperg N, Edelson MI, Mok SC, Johnson SW, Hamilton TC. The biology of ovarian cancer. Semin Oncol. 1998;25:281–304. - PubMed
    1. Auersperg N, Ota T, Mitchell GW. Early events in ovarian epithelial carcinogenesis: progress and problems in experimental approaches. Int J Gynecol Cancer. 2002;12:691–703. doi: 10.1046/j.1525-1438.2002.01152.x. - DOI - PubMed
    1. Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr Rev. 2001;22:255–288. doi: 10.1210/er.22.2.255. - DOI - PubMed

LinkOut - more resources