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Review
. 2009 Dec;59(6):517-26.

Acute phase response in animals: a review

Carolyn Cray  1 , Julia Zaias, Norman H Altman
Affiliations
Review

Acute phase response in animals: a review

Carolyn Cray et al. Comp Med. 2009 Dec.

Abstract

The acute phase response is a complex systemic early-defense system activated by trauma, infection, stress, neoplasia, and inflammation. Although nonspecific, it serves as a core of the innate immune response involving physical and molecular barriers and responses that serve to prevent infection, clear potential pathogens, initiate inflammatory processes, and contribute to resolution and the healing process. Acute phase proteins, an integral part of the acute phase response, have been a focus of many applications in human diagnostic medicine and recently have been identified in common animal species. Potential applications to diagnosis, prognosis, assessment of animal health, and laboratory animal welfare are readily apparent.

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Figures

Figure 1.
Figure 1.
The acute phase response. The figure reflects information drawn from references , , and .
Figure 2.
Figure 2.
Major and moderate acute phase proteins in different animal species. The figure reflects information drawn from references , , , , , , and .
Figure 3.
Figure 3.
Summary of acute phase responses by triggering event.
Figure 3.
Figure 3.
Summary of acute phase responses by triggering event.
See this image and copyright information in PMC

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References

    1. Abernethy JT, Avery OT. 1941. The occurence during acute infections of a protein not normally present in the blood. I. Distribution of the reactive protein in patients' sera and the effect of calicum on the flocculation reaction with C polysaccaride of Pneumococcus. J Exp Med 73:173–182 - PMC - PubMed
    1. Alper CA. 1974. Plasma protein measurements as a diagnostic aid. N Engl J Med 291:287–290 - PubMed
    1. Angen O, Thomsen J, Larsen LE, Larsen J, Kokotovic B, Heegaard PM, Enemark JM. 2009. Respiratory disease in calves: microbiological investigations on transtracheally aspirated bronchoalveolar fluid and acute phase protein response. Vet Microbiol 137:165–171 - PMC - PubMed
    1. Armstrong PB, Quigley JP. 1999. Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system. Dev Comp Immunol 23:375–390 - PubMed
    1. Arthington JD, Eichert SD, Kunkle WE, Martin FG. 2003. Effect of transportation and commingling on the acute-phase protein response, growth, and feed intake of newly weaned beef calves. J Anim Sci 81:1120–1125 - PubMed

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