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Review
. 2010 Mar;75(3):502-9.
doi: 10.1016/j.urology.2009.05.099. Epub 2009 Dec 29.

Reduction in the risk of prostate cancer: future directions after the Prostate Cancer Prevention Trial

E David Crawford  1 , Gerald L Andriole, Michael Marberger, Roger S Rittmaster
Affiliations
Review

Reduction in the risk of prostate cancer: future directions after the Prostate Cancer Prevention Trial

E David Crawford et al. Urology. 2010 Mar.

Abstract

The landmark Prostate Cancer Prevention Trial (PCPT) generated interest in the potential health benefits and cost of reducing prostate cancer risk--specifically, the potential role of 5alpha-reductase inhibitors. However, the PCPT raised several unanswered questions, including the cause and significance of the increased incidence of high-grade tumors associated with finasteride. In the present study, we review the PCPT findings and unanswered questions, next steps in this field, and ongoing prostate cancer prevention trials addressing these unanswered questions. Particular emphasis is placed on the design of the second large-scale trial of a 5alpha-reductase inhibitor, the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial.

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Comment in

  • Editorial comment.
    Thompson IM. Thompson IM. Urology. 2010 Mar;75(3):509-10. doi: 10.1016/j.urology.2009.06.056. Urology. 2010. PMID: 20211359 Free PMC article. No abstract available.

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