doi: 10.1016/j.leukres.2009.11.025.
Epub 2009 Dec 24.
Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9
Affiliations
- PMID: 20036004
- DOI: 10.1016/j.leukres.2009.11.025
Item in Clipboard
Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9
Leuk Res.
2010 Jun.
Abstract
Chemokines and their corresponding receptors participate in transmigration of leukemic cells. ERM (ezrin/radixin/moesin) protein family act as linkers between the plasma membrane and the cytoskeleton and are key component in tumor metastasis. In this study we used the CCR9-expressing acute T lymphocytic cell line MOLT4 as a model and assesssed their morphological and functional changes in response to CCL25. The pseudopodium formed and ERM translocated from the cytoplasm to the cell membrane following treatment with CCL25. Ezrin silencing by miRNA showed that ezrin plays important roles in the polarization and invasive behaviour of MOLT4 cells.
Copyright 2009 Elsevier Ltd. All rights reserved.
Similar articles
-
Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25.PLoS One. 2013;8(1):e52384. doi: 10.1371/journal.pone.0052384. Epub 2013 Jan 9. PLoS One. 2013. PMID: 23326330 Free PMC article.
-
ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.Biochimie. 2011 May;93(5):954-61. doi: 10.1016/j.biochi.2011.01.017. Epub 2011 Feb 23. Biochimie. 2011. PMID: 21352885
-
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation.J Cell Biol. 2004 Oct 25;167(2):327-37. doi: 10.1083/jcb.200403091. J Cell Biol. 2004. PMID: 15504914 Free PMC article.
-
Pathophysiological Roles of Ezrin/Radixin/Moesin Proteins.Biol Pharm Bull. 2017;40(4):381-390. doi: 10.1248/bpb.b16-01011. Biol Pharm Bull. 2017. PMID: 28381792 Review.
-
Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton.Int J Biochem Cell Biol. 2008;40(3):344-9. doi: 10.1016/j.biocel.2007.02.012. Epub 2007 Feb 22. Int J Biochem Cell Biol. 2008. PMID: 17419089 Review.
Cited by
-
NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia.Oncol Lett. 2017 Oct;14(4):4256-4262. doi: 10.3892/ol.2017.6716. Epub 2017 Aug 3. Oncol Lett. 2017. PMID: 28943936 Free PMC article.
-
Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia.Cell Oncol (Dordr). 2021 Oct;44(5):1105-1117. doi: 10.1007/s13402-021-00621-0. Epub 2021 Jul 1. Cell Oncol (Dordr). 2021. PMID: 34196912
-
CCL25 Signaling in the Tumor Microenvironment.Adv Exp Med Biol. 2021;1302:99-111. doi: 10.1007/978-3-030-62658-7_8. Adv Exp Med Biol. 2021. PMID: 34286444
-
The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells.Nucleic Acids Res. 2018 Feb 28;46(4):1793-1809. doi: 10.1093/nar/gkx1259. Nucleic Acids Res. 2018. PMID: 29253179 Free PMC article.
-
CCR9 in cancer: oncogenic role and therapeutic targeting.J Hematol Oncol. 2016 Feb 16;9:10. doi: 10.1186/s13045-016-0236-7. J Hematol Oncol. 2016. PMID: 26879872 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
