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Comment
. 2010 Jan;42(1):16-7.
doi: 10.1038/ng0110-16.

Getting connected in the globin interactome

Tobias Ragoczy, Mark Groudine
Comment

Getting connected in the globin interactome

Tobias Ragoczy et al. Nat Genet. 2010 Jan.

Abstract

A new study provides compelling evidence that transcriptional regulation and three-dimensional genomic architecture are linked. The alpha- and beta-globin loci associate with hundreds of active genes across the genome at transcription factories in erythroid cells, and specialized Klf1-containing transcription factories mediate the association of Klf1-regulated genes.

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