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Case Reports
. 2010 Apr;20(2):200-4.
doi: 10.1007/s10165-009-0254-1.

Marked effect and steroid-sparing ability of anakinra on a patient with refractory adult-onset Still's disease

Hiromichi Tamaki  1 , Hisanori Shimizu, Eiji Hiraoka, Eishi Uechi, Mitsumasa Kishimoto, Kenichi Yamaguchi, Masato Okada
Affiliations
Case Reports

Marked effect and steroid-sparing ability of anakinra on a patient with refractory adult-onset Still's disease

Hiromichi Tamaki et al. Mod Rheumatol. 2010 Apr.

Abstract

We report a case of refractory adult-onset Still's disease (AOSD) successfully controlled with anakinra, an interleukin-1 (IL-1) receptor antagonist. The patient was a 23-year-old Japanese woman with AOSD who could not be induced into remission despite of two courses of pulsed methylprednisolone followed by high-dose glucocorticoid administration in conjunction with high-dose intravenously administered gamma-globulin and methotrexate. To the best of our knowledge, this is the first case report in Japan of AOSD remission induced with anakinra.

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