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Review
. 2010 Jan 5;74 Suppl 1(Suppl 1):S31-40.
doi: 10.1212/WNL.0b013e3181c97ed3.

Monoclonal antibodies in MS: mechanisms of action

Bibiana Bielekova  1 , Brenda L Becker
Affiliations
Review

Monoclonal antibodies in MS: mechanisms of action

Bibiana Bielekova et al. Neurology. .

Abstract

The development of monoclonal antibodies (mAbs) presents an emerging, highly specific therapeutic strategy for the treatment of multiple sclerosis (MS). mAbs target selective molecules and have shown early promise, along with notable risks, in the treatment of MS and other immune-mediated diseases. The mechanism of action of the 4 mAbs under active investigation for MS (natalizumab, rituximab, alemtuzumab, and daclizumab) are reviewed, with a discussion of how mAb interaction with each target antigen may produce direct and indirect effects (proven and hypothesized) on immune cell activity, CNS-related inflammatory processes, and clinical outcomes.

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Figures

Figure 1.
Figure 1.
The properties of the mAb in regard to the target molecule (Fab-dependent),,,,
Figure 2.
Figure 2.
The effector function of mAb (Fc-dependent), NK, natural killer; DCs, dendritic cells; MФ, macrophages
See this image and copyright information in PMC

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