Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Apr;33(4):820-2.
doi: 10.2337/dc09-1573. Epub 2009 Dec 29.

Prevalence of type 1 diabetes autoantibodies (GADA, IA2, and IAA) in overweight and obese children

Valentina M Cambuli  1 , Michela Incani, Efisio Cossu, Tiziana Congiu, Francesca Scano, Sabrina Pilia, Federica Sentinelli, Claudio Tiberti, M Gisella Cavallo, Sandro Loche, Marco G Baroni
Affiliations

Prevalence of type 1 diabetes autoantibodies (GADA, IA2, and IAA) in overweight and obese children

Valentina M Cambuli et al. Diabetes Care. 2010 Apr.

Abstract

Objective: Little is known about the prevalence of beta-cell autoantibodies in children with excess body weight. The prevalence of type 1 diabetes autoantibodies and its relation with hyperglycemia was analyzed in 686 overweight/obese children and adolescents.

Research design and methods: All children underwent an oral glucose tolerance test, and anti-GAD, anti-IA2, and anti-IAA autoantibodies were measured. Autoantibody prevalence was evaluated in 107 normal-weight children for comparison.

Results: A single autoantibody was present in 2.18% of overweight/obese subjects and 1.86% normal-weight subjects (P = NS). Postload glycemia was significantly higher in antibody-positive children (133 +/- 69.9 vs. 105.4 +/- 17.7 mg/dl, P < 0.0001) compared with autoantibody-negative subjects. No difference in autoantibody distribution was seen when our cohort was stratified by age, sex, SDS-BMI, pubertal stage, and homeostasis model assessment-insulin resistance (HOMA-IR).

Conclusions: The 2.18% prevalence of type 1 diabetes autoantibodies is similar to that reported in nonobese children. This study provided evidence that excess body weight and insulin resistance do not influence autoantibody frequency.

PubMed Disclaimer

References

    1. Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G. the EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet 2009;373:2027–2033 - PubMed
    1. Hyppönen E, Virtanen SM, Kenward MG, Knip M, Åkerblom HK. the Childhood Diabetes in Finland Study Group. Obesity, increased linear growth, and risk of type I diabetes in children. Diabetes Care 2000;23:1755–1760 - PubMed
    1. Wilkin TJ. The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes. Int J Obes (Lond) 2009;33:716–726 - PubMed
    1. Dabelea D, D'Agostino RB, Jr, Mayer-Davis EJ, Pettitt DJ, Imperatore G, Dolan LM, Pihoker C, Hillier TA, Marcovina SM, Linder B, Ruggiero AM, Hamman RF. SEARCH for Diabetes in Youth Study Group: Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes. Diabetes Care 2006;29:1462–1463 - PubMed
    1. Casu A, Pascutto C, Bernardinelli L, Songini M. the Sardinian IDDM Epidemiology Study Group. Type 1 diabetes among Sardinian children is increasing: the Sardinian Diabetes register 0–14 years, 1989–1999. Diabetes Care 2004;27:1623–1629 - PubMed

Publication types