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. 2010 Jan;33(1):174-6.
doi: 10.2337/dc09-0101.

Altered C-fiber function as an indicator of early peripheral neuropathy in individuals with impaired glucose tolerance

Alistair Q Green  1 , Singhan Krishnan, Francis M Finucane, Gerry Rayman
Affiliations

Altered C-fiber function as an indicator of early peripheral neuropathy in individuals with impaired glucose tolerance

Alistair Q Green et al. Diabetes Care. 2010 Jan.

Abstract

Objective: This study explored the importance of glycemic burden compared with features of the metabolic syndrome in the pathogenesis of diabetic neuropathy by comparing C-fiber function in people with type 1 diabetes to that in people with impaired glucose tolerance (IGT).

Research design and methods: The axon reflex-elicited flare areas (LDIflares) were measured with a laser Doppler imager (LDI) in age-, height-, and BMI-matched groups with IGT (n = 14) and type 1 diabetes (n = 16) and in healthy control subjects (n = 16).

Results: The flare area was reduced in the IGT group compared with the control (2.78 +/- 1.1 vs. 5.23 +/- 1.7 cm(2), P = 0.0001) and type 1 diabetic (5.16 +/- 2.3 cm(2), P = 0.002) groups, whereas the flare area was similar in the type 1 diabetic and control groups.

Conclusions: This technique suggests that small-fiber neuropathy is a feature of IGT. The absence of similar small-fiber neuropathy in those with longstanding type 1 diabetes suggests that glycemia may not be the major determinant of small-fiber neuropathy in IGT.

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References

    1. Krishnan ST, Rayman G: The LDIflare: a novel test of C-fiber function demonstrates early neuropathy in type 2 diabetes. Diabetes Care 2004; 27: 2930– 2935 - PubMed
    1. Malik RA, Kallinikos P, Abbott CA, van Schie CH, Morgan P, Efron N, Boulton AJ: Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia 2003; 46: 683– 688 - PubMed
    1. Shun CT, Chang YC, Wu HP, Hsieh SC, Lin WM, Lin YH, Tai TY, Hsieh ST: Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments. Brain 2004; 127: 1593– 1605 - PubMed
    1. Gordon Smith A, Robinson Singleton J: Idiopathic neuropathy, prediabetes and the metabolic syndrome. J Neurol Sci 2006; 242: 9– 14 - PubMed
    1. Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C, Witte DR, Fuller JH: EURODIAB Prospective Complications Study Group. Vascular risk factors and diabetic neuropathy. N Engl J Med 2005; 352: 341– 350 - PubMed