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. 2008 Dec;12(3):107-11.
doi: 10.4103/0019-5278.44690.

Neopterin: Biomarker of cell-mediated immunity and potent usage as biomarker in silicosis and other occupational diseases

Shubhangi K Pingle  1 , Rajani G Tumane, Aruna A Jawade
Affiliations

Neopterin: Biomarker of cell-mediated immunity and potent usage as biomarker in silicosis and other occupational diseases

Shubhangi K Pingle et al. Indian J Occup Environ Med. 2008 Dec.

Abstract

Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with gamma-interferon. An international group acknowledges the fact that the levels of serum neopterin can be used as a marker of the effect of exposure to silica and other occupational diseases. The determination of neopterin is an innovative tool for monitoring diseases associated with the activation of cell-mediated immunity.

Keywords: Biomarker; cell-mediated immunity; neopterin; silicosis; tryptophan degradation; γ-interferon.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Mechanism of Neopterin Activation
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