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. 2010 Mar;84(6):3127-30.
doi: 10.1128/JVI.02184-09. Epub 2009 Dec 30.

Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses

Jens C Krause  1 , Terrence M Tumpey, Chelsey J Huffman, Patricia A McGraw, Melissa B Pearce, Tshidi Tsibane, Rong Hai, Christopher F Basler, James E Crowe Jr
Affiliations

Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses

Jens C Krause et al. J Virol. 2010 Mar.

Abstract

The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.

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Figures

FIG. 1.
FIG. 1.
Therapeutic efficacy of 1918 HA-specific MAbs against disease caused by the 2009 A (H1N1) virus in mice. In each group, five mice were followed every other day for weight. MAb 2D1 at 200-μg or 20-μg doses prevented weight loss at all time points after virus inoculation, compared to the control; (P < 0.002 for all by analysis of variance [ANOVA]). Neither MAb 2B12 nor human immunoglobulin (Hu Ig) mediated a statistically significant effect.
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