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Review
. 2010 Jan;9(1):29-42.
doi: 10.1038/nrd2897.

Subcellular targeting strategies for drug design and delivery

Lawrence Rajendran  1 , Hans-Joachim Knölker, Kai Simons
Affiliations
Review

Subcellular targeting strategies for drug design and delivery

Lawrence Rajendran et al. Nat Rev Drug Discov. 2010 Jan.

Abstract

Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design. In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery.

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References

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