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Case Reports
. 2010 Feb;33(2):E50-1.
doi: 10.1002/clc.20631.

Drink, drugs, and the QT interval

Robin A P Weir  1 , Colin J Petrie, Charles Angus Murphy, Henry J Dargie
Affiliations
Case Reports

Drink, drugs, and the QT interval

Robin A P Weir et al. Clin Cardiol. 2010 Feb.

Abstract

The effects of several prescription and illicitly-used drugs on electrocardiographic repolarization are well documented, most frequently manifested as prolongation of the corrected QT (QTc) interval. The combination of multiple repolarization-modulating drugs taken in high dosage can occasionally lead to extreme abnormalities of the QTc interval and ST-segment on the surface ECG, which can lead to the erroneous diagnosis of underlying myocardial ischemia and inappropriate treatment. We report on one such case in which the acute management of a syncopal patient was detrimentally influenced by misinterpretation of a very unusual ECG.

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References

    1. Bazett HC. An analysis of the time‐relations of electrocardiograms. Heart 1920; (7): 353–370.
    1. Haverkamp W, Breithardt G, Camm AJ, et al. The potential for QT prolongation and pro‐arrhythmia by non‐anti‐arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology. Cardiovasc Res 2000; 47(2): 219–233. - PubMed
    1. De Ponti F, Poluzzi E, Montanaro N. Organising evidence on QT prolongation and occurrence of torsades de pointes with non‐antiarrhythmic drugs: a call for consensus. Eur J Clin Pharmacol 2001; 57(3): 185–209. - PubMed
    1. Krantz MJ, Rowan SB, Mehler PS. Cocaine‐related torsade de pointes in a methadone maintenance patient. J Addict Dis 2005; 24(1): 53–60. - PubMed
    1. Chugh SS, Socoteanu C, Reinier K, et al. A community‐based evaluation of sudden death associated with therapeutic levels of methadone. Am J Med 2008; 121(1): 66–71. - PMC - PubMed

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