doi: 10.1016/0092-8674(91)90265-z.
Oct-3 is a maternal factor required for the first mouse embryonic division
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- PMID: 2004418
- DOI: 10.1016/0092-8674(91)90265-z
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Oct-3 is a maternal factor required for the first mouse embryonic division
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Retraction in
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Retraction: Oct-3 is a maternal factor required for the first mouse embryonic division.Cell. 1992 May 29;69(5):724. doi: 10.1016/0092-8674(92)90284-j. Cell. 1992. PMID: 1591774 No abstract available.
Abstract
Oct-3 is a POU domain transcription factor that binds the octamer DNA motif and is present in mouse oocytes before and after fertilization. When fertilized oocytes were injected with antisense Oct-3 oligonucleotides or double-stranded DNA containing the octamer motif, embryonic DNA synthesis was inhibited and the embryos were arrested at the one-cell stage. In vitro synthesized Oct-3 mRNA rescued the developmental block induced by antisense Oct-3 oligonucleotide. We conclude that maternally inherited Oct-3 is required for DNA replication and division of the one-cell embryo.
Comment in
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Final findings of scientific misconduct.NIH Guide Grants Contracts (Bethesda). 1993 Jun 25;22(23):1-4. NIH Guide Grants Contracts (Bethesda). 1993. PMID: 8390275 Free PMC article. No abstract available.
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