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. 1991 Mar 22;64(6):1103-10.
doi: 10.1016/0092-8674(91)90265-z.

Oct-3 is a maternal factor required for the first mouse embryonic division

M H Rosner  1 , R J De Santo, H Arnheiter, L M Staudt
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Free article

Oct-3 is a maternal factor required for the first mouse embryonic division

M H Rosner et al. Cell. .
Free article

Retraction in

Abstract

Oct-3 is a POU domain transcription factor that binds the octamer DNA motif and is present in mouse oocytes before and after fertilization. When fertilized oocytes were injected with antisense Oct-3 oligonucleotides or double-stranded DNA containing the octamer motif, embryonic DNA synthesis was inhibited and the embryos were arrested at the one-cell stage. In vitro synthesized Oct-3 mRNA rescued the developmental block induced by antisense Oct-3 oligonucleotide. We conclude that maternally inherited Oct-3 is required for DNA replication and division of the one-cell embryo.

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  • Final findings of scientific misconduct.
    [No authors listed] [No authors listed] NIH Guide Grants Contracts (Bethesda). 1993 Jun 25;22(23):1-4. NIH Guide Grants Contracts (Bethesda). 1993. PMID: 8390275 Free PMC article. No abstract available.

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