Comparative Study
doi: 10.1016/j.bmcl.2009.12.069.
Epub 2009 Dec 23.
Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem
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- PMID: 20044254
- DOI: 10.1016/j.bmcl.2009.12.069
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Comparative Study
Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem
Bioorg Med Chem Lett.
.
Abstract
Bridged monobactam beta-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C beta-lactamase mediated resistance. The (S)-azepine analog 2 was found to be effective in both in vitro and in vivo assays and was selected for preclinical development.
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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