Determination of product shelf life and activation energy for five drugs of abuse
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- PMID: 2004447
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Determination of product shelf life and activation energy for five drugs of abuse
Clin Chem.
1991 Mar.
Abstract
Estimating the shelf life of reagents and controls is a critical step in evaluating new formulations. We describe several stability assessment techniques, giving particular attention to experimental design. Activation energy was experimentally determined for five major drugs of abuse and metabolites: morphine, 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid, amphetamine, phencyclidine, and benzoylecgonine. The use of activation energy in establishing shelf life is illustrated for SENTRY (Hycor Biomedical Inc.) Drugs of Abuse Screen Control, a liquid urine-based product.
Comment in
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Determination of stability.Clin Chem. 1991 Mar;37(3):313-4. Clin Chem. 1991. PMID: 2004436 No abstract available.
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