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. 2010 Apr;119(4):509-11.
doi: 10.1007/s00401-009-0632-y. Epub 2010 Jan 1.

Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis

Sandra Camelo-Piragua, Michael Jansen, Aniruddha Ganguly, J Chulmin Kim, David N Louis, Catherine L Nutt

Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis

Sandra Camelo-Piragua et al. Acta Neuropathol. 2010 Apr.
No abstract available

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Conflict of interest statement

Conflict of interest statement The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
R132H mutant IDH1 immunohistochemistry in WHO grade II astrocytoma and astrocytosis. Strong granular cytoplasmic mutant IDH1 staining in cellular area of astrocytoma (a H&E; b mutant IDH1) and in infiltrating tumor cells (c H&E; d mutant IDH1); example of two cases, individual mutant IDH1-positive infiltrating tumor cells in cortex (d upper panels, case 18) and at the edge of the tumor (d bottom panel, case 4). Marked astrocytosis adjacent to an infarct positive for GFAP (e) and negative for mutant IDH1 (f). Magnification a–f = 400×; d, upper panels = 1,000×
See this image and copyright information in PMC

References

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