doi: 10.1016/j.ejmech.2009.11.049.
Epub 2009 Dec 11.
6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line
Affiliations
- PMID: 20045224
- DOI: 10.1016/j.ejmech.2009.11.049
Item in Clipboard
6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line
Eur J Med Chem.
2010 Mar.
Abstract
A series of 6-substituted 2-(N-trifluoroacetylamino)imidazopyridines have been synthesized and their bioactivities were evaluated. Compounds 6a, 6c, and 11a were the most active compounds with modest cytotoxic activity against six human cancer cell lines U251 (glioma), PC-3 (prostate), K-562 (leukemia), HCT-15 (colon), MCF7 (breast) and SK-LU-1 (lung). The cell cycle analysis showed that compounds 6a, 6c, and 11a induce a G2/M phase cell cycle arrest on SK-LU-1 cell line where inhibition of CDK-1 and CDK-2 may be implicated.
Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
Similar articles
-
Zoledronic acid is unable to induce apoptosis, but slows tumor growth and prolongs survival for non-small-cell lung cancers.Lung Cancer. 2008 Feb;59(2):180-91. doi: 10.1016/j.lungcan.2007.08.026. Epub 2007 Sep 27. Lung Cancer. 2008. PMID: 17900752
-
Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells.Bioorg Med Chem Lett. 2004 Oct 18;14(20):5175-8. doi: 10.1016/j.bmcl.2004.07.062. Bioorg Med Chem Lett. 2004. PMID: 15380222
-
[Synthesis and antitumor activity of arylsubstituted imidazolin-2-one derivatives].Yao Xue Xue Bao. 2005 Aug;40(8):711-6. Yao Xue Xue Bao. 2005. PMID: 16268505 Chinese.
-
Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at G1 in U251MG human glioma cell line.Cancer Chemother Pharmacol. 2003 Apr;51(4):271-83. doi: 10.1007/s00280-002-0562-z. Epub 2003 Mar 20. Cancer Chemother Pharmacol. 2003. PMID: 12721754
-
Recent Developments in the Photochemical Synthesis of Functionalized Imidazopyridines.Molecules. 2022 May 27;27(11):3461. doi: 10.3390/molecules27113461. Molecules. 2022. PMID: 35684399 Free PMC article. Review.
Cited by
-
Crystal structure, Hirshfeld surface analysis and DFT studies of 6-bromo-3-(12-bromo-dodec-yl)-2-(4-nitro-phen-yl)-4H-imidazo[4,5-b]pyridine.Acta Crystallogr E Crystallogr Commun. 2020 Apr 21;76(Pt 5):677-682. doi: 10.1107/S2056989020005228. eCollection 2020 May 1. Acta Crystallogr E Crystallogr Commun. 2020. PMID: 32431932 Free PMC article.
-
A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization.Int J Mol Sci. 2022 Apr 4;23(7):4001. doi: 10.3390/ijms23074001. Int J Mol Sci. 2022. PMID: 35409361 Free PMC article. Review.
-
A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A2.PLoS One. 2015 Jul 21;10(7):e0131896. doi: 10.1371/journal.pone.0131896. eCollection 2015. PLoS One. 2015. PMID: 26196520 Free PMC article.
-
Cyclin-dependent kinase inhibitors and the treatment of gastrointestinal cancers.Am J Pathol. 2015 May;185(5):1185-97. doi: 10.1016/j.ajpath.2015.01.008. Epub 2015 Mar 5. Am J Pathol. 2015. PMID: 25747534 Free PMC article. Review.
-
Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction.Mol Divers. 2021 Feb;25(1):509-516. doi: 10.1007/s11030-019-10029-6. Epub 2020 Jan 9. Mol Divers. 2021. PMID: 31919737
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
