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. 2010 Mar;45(3):1211-9.
doi: 10.1016/j.ejmech.2009.11.049. Epub 2009 Dec 11.

6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line

Miguel Angel Martínez-Urbina  1 , Alejandro Zentella, Miguel Angel Vilchis-Reyes, Angel Guzmán, Omar Vargas, María Teresa Ramírez Apan, José Luis Ventura Gallegos, Eduardo Díaz
Affiliations

6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line

Miguel Angel Martínez-Urbina et al. Eur J Med Chem. 2010 Mar.

Abstract

A series of 6-substituted 2-(N-trifluoroacetylamino)imidazopyridines have been synthesized and their bioactivities were evaluated. Compounds 6a, 6c, and 11a were the most active compounds with modest cytotoxic activity against six human cancer cell lines U251 (glioma), PC-3 (prostate), K-562 (leukemia), HCT-15 (colon), MCF7 (breast) and SK-LU-1 (lung). The cell cycle analysis showed that compounds 6a, 6c, and 11a induce a G2/M phase cell cycle arrest on SK-LU-1 cell line where inhibition of CDK-1 and CDK-2 may be implicated.

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