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. 2010 Mar;9(2):110-6.
doi: 10.1016/j.jcf.2009.11.010. Epub 2009 Dec 31.

Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis

Christopher R Sudfeld  1 , Elliott C Dasenbrook, William G Merz, Karen C Carroll, Michael P Boyle
Affiliations

Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis

Christopher R Sudfeld et al. J Cyst Fibros. 2010 Mar.

Abstract

Background: Filamentous fungi are frequently recovered from respiratory cultures of individuals with CF.

Methods: A CF cohort database was utilized to determine filamentous fungal prevalence and risk factors.

Results: The prevalence of filamentous fungal isolation increased from 2.0% in 1997 to 28.7% in 2007. The odds of isolating filamentous fungi during a quarter was greater in CF adults [p<0.001], during chronic oral antibiotic use [p=0.002] and increased with each 10% drop in FEV(1) percent predicted [p=0.005], while inhaled corticosteroids surprisingly decreased the likelihood [p=0.012]. The direction of these effects persisted after excluding individuals with ABPA. A sub-analysis determined older age [p=0.019] and use of inhaled antibiotics [p=0.011] were independent risk factors for onset of fungal colonization.

Conclusions: This study suggests that isolation of filamentous fungi in CF at JHH has increased and risk factors include older age, decreased lung function, and chronic oral antibiotics.

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Conflict of interest statement

Conflict of Interest: None Reported

Figures

Figure I
Figure I
Percentage of Individuals Recovering at Least One Filamentous Fungal Species from Lung Culture During Each Year 1997–2007.
See this image and copyright information in PMC

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