Phosphatase of regenerating liver-3: a novel and promising marker in human endometriosis

Abstract

Objective: To investigate the expression of phosphatase of regenerating liver-3 (PRL-3) in ectopic, eutopic, and normal endometria and explore its relationship with endometriosis.

Design: A clinical retrospective and molecular study.

Setting: Department of obstetrics, gynecology, and reproductive medicine.

Patient(s): One hundred and five women with histopathologically confirmed endometriosis, and 50 women with histopathologically assessed normal endometria.

Intervention(s): Immunohistochemical staining and Western blot analysis.

Main outcome measure(s): Expression of PRL-3 protein.

Result(s): As shown by the immunohistochemical analysis, PRL-3 was mainly located in the cytoplasm and membrane. The cells that tested positive for PRL-3 were detected in endometriotic tissues that did not occur in eutopic and normal endometria. Statistical analysis indicated that the expression of PRL-3 was closely associated with the clinical stages and recurrence of endometriosis.

Conclusion(s): Expression of PRL-3 is related to the clinical stages and recurrence of endometriosis, which provides use with a novel marker and promising target in the treatment of human endometriosis.