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Comparative Study
. 2010 Feb 1;20(3):927-31.
doi: 10.1016/j.bmcl.2009.12.075. Epub 2009 Dec 24.

Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate

Yuanqing Zhang  1 , Yanhong Sun, Xiaoping Xu, Hua Zhu, Liliang Huang, Xuezhu Zhang, Yujin Qi, Yu-Mei Shen
Affiliations
Comparative Study

Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate

Yuanqing Zhang et al. Bioorg Med Chem Lett. .

Abstract

Acetylated (Ac) dendrimer poly(amido)-amine (PAMAM) generation 5 (G5) reacted with folic acid (FA), followed by reacting with 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M DTPA) to form the conjugate of Ac-G5-FA-1B4M DTPA which was further radiolabeled with (99m)Tc. The radiochemical yield is up to 98.9% with excellent in vitro/in vivo stability, rapid blood clearance and certain tumor accumulation which was further confirmed by micro-SPECT imaging study.

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