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Comparative Study
. 2010 Feb 1;20(3):954-7.
doi: 10.1016/j.bmcl.2009.12.061. Epub 2009 Dec 22.

New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein

Louise Stevenson  1 , Adriana A S Tavares, Aurélie Brunet, Fiona I McGonagle, Deborah Dewar, Sally L Pimlott, Andrew Sutherland
Affiliations
Comparative Study

New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein

Louise Stevenson et al. Bioorg Med Chem Lett. .

Abstract

With the aim of developing new SPECT imaging agents for the translocator protein (TSPO), a small library of iodinated quinoline-2-carboxamides have been prepared and tested for binding affinity with TSPO. N,N-Diethyl-3-iodomethyl-4-phenylquinoline-2-carboxamide was found to have excellent affinity (K(i) 12.0 nM), comparable to that of the widely used TSPO imaging agent PK11195.

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