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. 2010 Feb;18(3):1227-35.
doi: 10.1016/j.bmc.2009.12.037. Epub 2009 Dec 22.

Square pyramidal copper(II) complexes with forth generation fluoroquinolone and neutral bidentate ligand: structure, antibacterial, SOD mimic and DNA-interaction studies

Mohan N Patel  1 , Pradhuman A Parmar, Deepen S Gandhi
Affiliations

Square pyramidal copper(II) complexes with forth generation fluoroquinolone and neutral bidentate ligand: structure, antibacterial, SOD mimic and DNA-interaction studies

Mohan N Patel et al. Bioorg Med Chem. 2010 Feb.

Abstract

Coordination of neutral bidentate ligand to copper ion in combination with gatifloxacin have been focused in this article. The effect of complexation reflects antibacterial activity, DNA interaction and SOD mimic activity of individual greatly. The geometry at the central metal ion provides a site for binding of superoxide anion responsible for better SOD mimic behaviour.

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