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Case Reports
. 2009 Dec 31;50(6):859-61.
doi: 10.3349/ymj.2009.50.6.859. Epub 2009 Dec 18.

Case of small bowel perforation due to enteropathy-type T-cell lymphoma

Yong Seok Kim  1 , Yoo Shin Choi, Jun Seok Park, Beom Gyu Kim, Seong Jae Cha, Kyong Choun Chi, Sung Jun Park, In Taik Chang, Sung Il Park
Affiliations
Case Reports

Case of small bowel perforation due to enteropathy-type T-cell lymphoma

Yong Seok Kim et al. Yonsei Med J. .

Abstract

Enteropathy-type T-cell lymphoma (ETTL) is a rare disease with a poor prognosis. According to the World Health Organization (WHO) classification, it is a subtype of the peripheral T-cell lymphomas. This disease is associated with gluten-sensitive enteropathy, has a high risk of intestinal perforation and obstruction, and is refractory to chemotherapeutic treatment. We report the case of a 73-year-old woman who was diagnosed with enteropathy-type T-cell lymphoma of the small intestine, which was positive for the markers of cytotoxic T cells, CD3, CD8, and CD56, on immunohistochemical staining after resection of the perforated terminal ileum.

Keywords: Enteropathy-type T-cell lymphoma; celiac disease; intestinal perforation.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
CT: wall thickening with central necrosis in small bowel and lymphadenopathies near the mass.
Fig. 2
Fig. 2
A gross pathological specimen: a well-defined encircling mural mass and perforated ulcers.
Fig. 3
Fig. 3
Histopathological findings in the affected terminal ileum. (A) Diffuse infiltration of atypical lymphocytes with irregularly shaped nuclei (Hematoxylin-Eosin stain, ×400). (B) Lymphoma cell infiltration by CD3-positive and CD20-negative T lymphocytes (immunohistochemical stain, ×400).
See this image and copyright information in PMC

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