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Randomized Controlled Trial
. 2010 Jan;51(1):88-92.
doi: 10.3349/ymj.2010.51.1.88. Epub 2009 Dec 29.

Comparison of azasetron and ondansetron for preventing postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery

Mi Ja Yun  1 , Yoon Hee Kim, A Rm Kim
Affiliations
Randomized Controlled Trial

Comparison of azasetron and ondansetron for preventing postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery

Mi Ja Yun et al. Yonsei Med J. 2010 Jan.

Abstract

Purpose: We compared the prophylactic effects of intravenously administered azasetron (10 mg) and ondansetron (8 mg) on postoperative nausea and vomiting (PONV) in patients undergoing gynecological laparoscopic surgery under general anesthesia.

Materials and methods: We studied 98 ASA physical status I or II 20-65 years old, female patients, in this prospective, randomized, double blind study. Patients were randomly divided into two groups and received ondansetron 8 mg (group O) or azasetron 10 mg (group A) 5 min before the end of surgery. The incidence of PONV, Visual Analogue Scale (VAS) for pain, need for rescue antiemetic and analgesics, and adverse effects were checked at 1, 6, 12, 24, and 48 h postoperatively.

Results: The overall incidence of PONV was 65% in group O and 49% in group A. The incidence of PONV was significantly higher in group O than in group A at 12-24 h postoperatively (nausea; 24% vs. 45%, p = 0.035, vomiting; 2% vs. 18%, p = 0.008), but there were no significant differences at 0-1, 1-6, 6-12 or 24-48 h.

Conclusion: In conclusion, azasetron (10 mg) produced same incidence of PONV as ondansetron (8 mg) in patients undergoing general anesthesia for gynecological laparoscopic surgery. Azasetron was more effective, in the intermediate post-operative period, between 12 and 24 h.

Keywords: Azasetron; gynecologic surgical procedures; ondansetron; postoperative nausea and vomiting; prophylaxis.

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Conflict of interest statement

The authors have no financial conflicts of interest.

References

    1. Gan TJ. Postoperative nausea and vomiting--can it be eliminated? JAMA. 2002;287:1233–1236. - PubMed
    1. Ismail S. Practice of use of antiemetic in patients for laparoscopic gynaecological surgery and its impact on the early (1st two hrs) postoperative period. J Pak Med Assoc. 2008;58:203–205. - PubMed
    1. Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S, et al. Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg. 2003;97:62–71. - PubMed
    1. White PF, Watcha MF. Postoperative nausea and vomiting: prophylaxis versus treatment. Anesth Analg. 1999;89:1337–1339. - PubMed
    1. Tsukagoshi S. [Pharmacokinetics of azasetron (Serotone), a selective 5-HT3 receptor antagonist.] Gan To Kagaku Ryoho. 1999;26:1001–1008. - PubMed

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