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. 2009 Jan;1(1):34-6.
doi: 10.4161/derm.1.1.7170.

Acquired ichthyosis associated with type 1 diabetes mellitus

Hatice Sanli  1 , Bengü Nisa Akay, Bilge Bulbul Sen, Aslihan Yonca Kocak, Rifat Emral, Seher Bostanci
Affiliations

Acquired ichthyosis associated with type 1 diabetes mellitus

Hatice Sanli et al. Dermatoendocrinol. 2009 Jan.

Abstract

Acquired ichthyosis is an uncommon disease which is characterized by symmetric scaling of the skin. Acquired ichthyosis has been described in association with a variety of underlying causes, including malignancies, drugs, infections, endocrine, metabolic and autoimmune diseases. Acquired ichthyosis associated with diabetes mellitus has been reported only in one case. We report the case of a new-onset diabetes mellitus with a one-month history of generalized acquired ichthyosis and palmoplantar keratoderma corroborated with skin biopsy, which completely disappeared after regulation of blood glucose levels with insulin therapy.

Keywords: acquired ichthyosis; diabetes mellitus; insulin deficiency; keratinization disorder; palmoplantar keratoderma.

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Figures

Figure 1
Figure 1
Ichthyosiform skin changes on the kness.
Figure 2
Figure 2
Plantar keratoderma.
Figure 3
Figure 3
Thinned epidermis with marked hyperkeratosis and absence of the epidermal granular layer. H-Ex40.
Figure 4
Figure 4
Ichthyosiform skin changes on the legs resolved after topical emollients and insulin therapy.
Figure 5
Figure 5
Plantar keratoderma resolved after 3% salicylic acid in vaseline and insulin therapy.
See this image and copyright information in PMC

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References

    1. Dykes PJ, Marks R. Acquired ichthyosis: Multiple causes for an acquired generalized disturbance in desquamation. Br J Dermatol. 1977;97:327–334. - PubMed
    1. DiGiovanna JJ. Ichthyosiform dermatoses. In: Freedberg IM, Eisen AZ, Wolff K, et al., editors. Fitzpatrick's dermatology in general medicine. New York: McGraw-Hill; 1999. pp. 581–603.
    1. Okulicz JF, Schwartz RA. Hereditary and acquired ichthyosis vulgaris. Int J Dermatol. 2003;42:95–98. - PubMed
    1. Schulz EJ. Ichthyosiform conditions occuring in leprosy. Br J Dermatol. 1965;77:151–157. - PubMed
    1. Goodman DS, Teplitz ED, Wishner A, Klein RS, Burk PG, Hershenbaum E. Prevalance of cutaneous disease in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. J Am Acad Dermatol. 1987;17:210–220. - PubMed

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