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. 2008 Mar-Apr;70(2):227-9.
doi: 10.4103/0250-474X.41461.

Antihyperglycemic Activity of Various Fractions of Cassia auriculata Linn. in Alloxan Diabetic Rats

S J Surana  1 , S B Gokhale, R B Jadhav, R L Sawant, Jyoti B Wadekar
Affiliations

Antihyperglycemic Activity of Various Fractions of Cassia auriculata Linn. in Alloxan Diabetic Rats

S J Surana et al. Indian J Pharm Sci. 2008 Mar-Apr.

Abstract

Present work describes the potent antidiabetic fraction from flowers of Cassia auriculata Linn. Hydromethanolic extract along with its ethyl acetate and n-butanol fractions were evaluated for antidiabetic activity in alloxan-induced diabetes in rats. The n-butanol fraction exhibited significant reduction (p<0.001) in blood glucose levels and was also found effective in restoring the blood lipids and proteins to normal level. The activity was found comparable with standard drug phenformin. The hydromethanolic extract and its fractions were subjected to preliminary qualitative chemical investigations which indicated the presence of phenolic compounds, carbohydrates, tannins, steroids and amino acids.

Keywords: Cassia auriculata; alloxan-induced diabetes; antidiabetic activity; hydromethanolic extract.

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