doi: 10.4103/0250-474X.43018.
High performance thin layer chromatographic method for simultaneous estimation of Ibuprofen and pseudoephedrine hydrochloride
Affiliations
- PMID: 20046759
- PMCID: PMC2792507
- DOI: 10.4103/0250-474X.43018
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High performance thin layer chromatographic method for simultaneous estimation of Ibuprofen and pseudoephedrine hydrochloride
Indian J Pharm Sci.
2008 May-Jun.
Abstract
High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F(254) plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wavelength selected for analysis was 254 nm. Percent estimation of ibuprofen and pseudoephedrine hydrochloride was found to be 99.56% and 98.77%, respectively. Percent recovery for both the drugs was found in the range of 98.27% to 100.91%, respectively.
Keywords: HPTLC; Ibuprofen; ethyl acetate; glacial acetic acid; pseudoephedrine hydrochloride; t-butanol; water.
Figures
Chromatogram of marketed formulation. 1- pseudoephedrine hydrochloride and 2- ibuprofen
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