Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jan 1;4(1):89-100.
doi: 10.1016/j.cpet.2009.04.014.

Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors

Andrew G Horti, Dean F Wong

Clinical Perspective and Recent Development of PET Radioligands for Imaging Cerebral Nicotinic Acetylcholine Receptors

Andrew G Horti et al. PET Clin. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
The currently available nAChR PET radioligands for human studies.
Fig. 2
Fig. 2
2-[18F]FA and its new analogs with improved imaging properties. aHigh accumulation of radioactivity in striatum suggests the presence of active radiolabeled metabolites.
Fig. 3
Fig. 3
Lead compounds for the recent development of nAChR radioligands.
Fig. 4
Fig. 4
Small animal PET image (summed 20–90 minutes) of [11C]JHU85157 in the rat brain. Courtesy of C.J. Endres, PhD, Baltimore, MD.
Fig. 5
Fig. 5
PET imaging properties of new radiolabeled analogs of epibatidine. aBaboon; bPiglets; cLipophilicity value (logarithm of partition coefficient between n-octanol and water at pH 7.4); dInhibition binding affinity. Cx = cortex, Th = thalamus.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nordberg A, Hartvig P, Lundqvist H, et al. Uptake and regional distribution of (+)-(R)- and (−)-(S)-N-[methyl-11C]-nicotine in the brains of rhesus monkey. An attempt to study nicotinic receptors in vivo. J Neural Transm Park Dis Dement Sect. 1989;1(3):195–205. - PubMed
    1. Lundqvist H, Nordberg A, Hartvig P, et al. (S)-(−)-[11C]nicotine binding assessed by PET: a dual tracer model evaluated in the rhesus monkey brain. Alzheimer Dis Assoc Disord. 1998;12(3):238–46. - PubMed
    1. Muzic RF, Jr, Berridge MS, Friedland RP, et al. PET quantification of specific binding of carbon-11-nicotine in human brain. J Nucl Med. 1998;39(12):2048–54. - PubMed
    1. Grunwald F, Biersack HJ, Kuschinsky W. Nicotine receptor mapping. Eur J Nucl Med. 1996;23(8):1012–4. - PubMed
    1. Kimes AS, Horti AG, London ED, et al. 2-[18F]F-A85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. FASEB J. 2003;17(10):1331–3. - PubMed

LinkOut - more resources