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. 2009 Jan 1;81(6):1051-1063.
doi: 10.1351/PAC-CON-08-10-16.

Discovery of anticancer agents of diverse natural origin

A Douglas Kinghorn  1 , Esperanza J Carcache de Blanco, Hee-Byung Chai, Jimmy Orjala, Norman R Farnsworth, D Doel Soejarto, Nicholas H Oberlies, Mansukh C Wani, David J Kroll, Cedric J Pearce, Steven M Swanson, Robert A Kramer, William C Rose, Craig R Fairchild, Gregory D Vite, Stuart Emanuel, David Jarjoura, Frederick O Cope
Affiliations

Discovery of anticancer agents of diverse natural origin

A Douglas Kinghorn et al. Pure Appl Chem. .

Abstract

A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.

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Figures

Figure 1
Figure 1
Organizational Scheme of Program Project
Figure 2
Figure 2
Structures of Compounds Isolated During Collaborative Work
See this image and copyright information in PMC

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