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Comment
. 2010 Jan 1;24(1):1-4.
doi: 10.1101/gad.1887110.

Tumorigenicity of the miR-17-92 cluster distilled

Gijs van Haaften  1 , Reuven Agami
Affiliations
Comment

Tumorigenicity of the miR-17-92 cluster distilled

Gijs van Haaften et al. Genes Dev. .

Abstract

The miR-17-92 gene cluster, with its six different mature microRNAs (miRNAs), has an established oncogenic function. However, the oncogenic contribution of each individual miRNA in the cluster has not been assigned. Two studies published in the December 15, 2009, issue of Genes & Development by Mu and colleagues (pp. 2806-2811) and Olive and colleagues (pp. 2839-2849) dissected the miR-17-92 cluster to its individual miRNA components and identified their relative contributions to oncogenic transformation in mouse model systems.

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Figures

Figure 1.
Figure 1.
(A) Clustering of the miRNAs of miR-17-92 and its paralogous clusters based on the regions most important for target selection (the seed sequences, nucleotides 2–7 of the mature miR). (B) Role of the miR-17-92 cluster in oncogenesis. The miR-17-92 cluster is a direct transcriptional target of c-Myc. miR-17/20a targets E2F1, a regulator of the cell cycle and apoptosis. miR-92 targets BIM, a proapoptotic gene that counteracts the anti-apoptotic activity of genes such as Bcl2. miR-19 targets PTEN, a negative regulator of the oncogenic prosurvival PI3K/AKT signaling pathway.
See this image and copyright information in PMC

Comment on

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