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Editorial
. 2010 Feb;55(2):233-5.
doi: 10.1161/HYPERTENSIONAHA.109.147256. Epub 2010 Jan 4.

Syndecan-1: a critical mediator in cardiac fibrosis

Nikolaos G Frangogiannis
Editorial

Syndecan-1: a critical mediator in cardiac fibrosis

Nikolaos G Frangogiannis. Hypertension. 2010 Feb.
No abstract available

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Figures

Figure
Figure
The role of Syndecan-1 (Synd1) in cardiac fibrosis. Synd1 may act by presenting growth factors to their receptors, may increase TGF-β receptor levels, may promote TGF-β activation, or may activate downstream TGF-β signaling pathways. Understanding the role of syndecan-1 in cardiac injury is complicated by the possible presence of shed ectodomains (released due to increased Matrix Metalloproteinase [MMP] activity), that may sequester growth factors, or promote chemotactic gradients (Ang II, angiotensin II).
See this image and copyright information in PMC

Comment on

  • Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis.
    Schellings MW, Vanhoutte D, van Almen GC, Swinnen M, Leenders JJ, Kubben N, van Leeuwen RE, Hofstra L, Heymans S, Pinto YM. Schellings MW, et al. Hypertension. 2010 Feb;55(2):249-56. doi: 10.1161/HYPERTENSIONAHA.109.137885. Epub 2010 Jan 4. Hypertension. 2010. PMID: 20048198

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