Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Jan 1;21(1):4-6.
doi: 10.1091/mbc.e09-07-0575.

It's the data!

Affiliations
Comment

It's the data!

David Botstein. Mol Biol Cell. .

Abstract

Three articles from the early years of Molecular Biology of the Cell (MBoC) have had remarkably many citations in the literature since their publication approximately 10 years ago. As a coauthor of these articles and the former editor of MBoC, I was asked for possible explanations. I believe the answer lies in the unusual nature of these articles: each presents and summarizes gene expression data for nearly every gene in the yeast or human genomes. Continuing interest in the data themselves by cell biologists, rather than results or conclusions drawn by the authors, best accounts for the citation history. The flatness of the numbers of citations over time, the continuing high rate of accesses to individual Web sites set up to allow searching and display of the underlying data, and the large fraction of citations in journals focused on mathematics and computation all support the same conclusion: it's the data.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The citation history of three articles from the early years of MBoC. Source: ISI database.

Comment on

Similar articles

Cited by

References

    1. Brown P. O., Botstein D. Exploring the new world of the genome with DNA microarrays. Nat. Genet. 1999;21(1 Suppl):33–37. - PubMed
    1. Gasch A. P., Spellman P. T., Kao C. M., Carmel-Harel O., Eisen M. B., Storz G., Botstein D., Brown P. O. Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell. 2000;11:4241–4257. - PMC - PubMed
    1. Spellman P. T., Sherlock G., Zhang M. Q., Iyer V. R., Anders K., Eisen M. B., Brown P. O., Botstein D., Futcher B. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell. 1998;9:3273–3297. - PMC - PubMed
    1. Whitfield M. L., et al. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol. Biol. Cell. 2002;13:1977–2000. - PMC - PubMed

LinkOut - more resources