[Calcium antagonists: current and future applications based on new evidence. Cardio-protective effect of calcium antagonists]

Abstract

Calcium antagonists block calcium influx through the L-type calcium channel to produce dilatation of resistant arteries including coronary arteries. Due to arterial vasodilatation, calcium antagonists have beneficial effects for ischemic heart disease, left ventricular hypertrophy and heart failure. Some of calcium antagonists are known to have the inhibitory action for T-type or N-type calcium channel which might be beneficial for the inhibition of reactive tachycardia. Calcium antagonists may also retard the progression of atherosclerosis to prevent cardiovascular events.