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. 2009 Nov;117(11):1767-72.
doi: 10.1289/ehp.0900591. Epub 2009 Jul 31.

Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study

Irina Mordukhovich  1 , Elissa Wilker, Helen Suh, Robert Wright, David Sparrow, Pantel S Vokonas, Joel Schwartz
Affiliations

Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study

Irina Mordukhovich et al. Environ Health Perspect. 2009 Nov.

Abstract

Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies have investigated the relationship between PM and BP and found mixed results. Evidence suggests that traffic-related air pollution contributes significantly to PM-related cardiovascular effects.

Objectives: We hypothesized that black carbon (BC), a traffic-related combustion by-product, would be more strongly associated with BP than would fine PM [aerodynamic diameter < or = 2.5 microm (PM(2.5))], a heterogeneous PM mixture, and that these effects would be larger among participants with genetic variants associated with impaired antioxidative defense.

Methods: We performed a repeated-measures analysis in elderly men to analyze associations between PM(2.5) and BC exposure and BP using mixed-effects models with random intercepts, adjusting for potential confounders. We also examined statistical interaction between BC and genetic variants related to oxidative stress defense: GSTM1, GSTP1, GSTT1, NQO1, catalase, and HMOX-1.

Results: A 1-SD increase in BC concentration was associated with a 1.5-mmHg increase in systolic BP [95% confidence interval (CI), 0.1-2.8] and a 0.9-mmHg increase in diastolic BP (95% CI, 0.2-1.6). We observed no evidence of statistical interaction between BC and any of the genetic variants examined and found no association between PM(2.5) and BP.

Conclusions: We observed positive associations between BP and BC, but not between BP and PM(2.5), and found no evidence of effect modification of the association between BC and BP by gene variants related to antioxidative defense.

Keywords: black carbon; blood pressure; epidemiology; gene–environment interactions; human; oxidative stress; particulate matter.

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