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. 2009 Dec;39(12):532-7.
doi: 10.4070/kcj.2009.39.12.532. Epub 2009 Dec 30.

Characteristics of myocardial deformation and rotation in subjects with diastolic dysfunction without diastolic heart failure

Hee Sang Jang  1 , Jae Hoon Kim, Byung Seok Bae, Seung Min Shin, Ki Ju Kim, Jung Gil Park, Hyun Jae Kang, Bong Ryeol Lee, Byung Chun Jung
Affiliations

Characteristics of myocardial deformation and rotation in subjects with diastolic dysfunction without diastolic heart failure

Hee Sang Jang et al. Korean Circ J. 2009 Dec.

Abstract

Background and objectives: There have been very few pathophysiologic studies on isolated diastolic dysfunction. We hypothesized that the characteristics of isolated diastolic dysfunction would be located, on the clinical continuum, between those of a normal heart and diastolic heart failure.

Subjects and methods: We enrolled 102 subjects who had no history of overt symptoms of heart failure and who had a left ventricular ejection fraction of more than 50%. They were examined for myocardial deformation and rotation using the two-dimensional speckle tracking image (2D-STI) technique.

Results: The circumferential strains and radial strain at the apical level (RS(apex)) were related to the ratio of the transmitral early peak velocity over the early diastolic mitral annulus velocity (E/E'). After adjustment for age, the RS(apex) showed a positive relationship with the E/E' ratio; whereas, the circumferential strains did not. Instead, the circumferential strains demonstrated a significant correlation with age. Basal rotation and left ventricular (LV) torsion were also related to age, but had no relationship with the E/E' ratio. However, as the E/E' ratio value increased, systolic mitral annular velocity decreased.

Conclusion: Except for the RS(apex), LV myocardial deformation and rotation did not vary with the degree of E/E' ratio elevation when there was no associated diastolic heart failure. Additionally, in clinical situations such as isolated diastolic dysfunction, the advancement of age has a relatively greater influence on characteristics of LV myocardial deformation and rotation rather than on the E/E' ratio.

Keywords: E/E' Ratio; Echocardiography, Doppler; Heart failure, diastolic.

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Figures

Fig. 1
Fig. 1
Correlation of radial strain at apex level (RSapex) with the E/E' ratio (A) and age (B). RSapex had a tendency to increase with increments in the E/E' ratio, but not with age.
See this image and copyright information in PMC

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