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. 2010:2010:235035.
doi: 10.1155/2010/235035. Epub 2009 Dec 9.

Circulating 25-hydroxyvitamin d levels in fully breastfed infants on oral vitamin d supplementation

Carol L Wagner  1 , Cindy Howard, Thomas C Hulsey, Ruth A Lawrence, Sarah N Taylor, Heather Will, Myla Ebeling, Jay Hutson, Bruce W Hollis
Affiliations

Circulating 25-hydroxyvitamin d levels in fully breastfed infants on oral vitamin d supplementation

Carol L Wagner et al. Int J Endocrinol. 2010.

Abstract

Objective. To examine the effectiveness of oral vitamin D(3) (400 IU) supplementation on the nutritional vitamin D status of breastfeeding infants. Design. As part of a larger ongoing vitamin D RCT trial of lactating women, infants of mothers assigned to control received 1 drop of 400 IU vitamin D(3)/day starting at one month of age. Infant 25(OH)D levels (mean +/- S.D.) were measured by RIA at visits 1, 4, and 7. Results. The infant mean +/- S.D. 25(OH)D at baseline was 16.0 +/-9.3 ng/mL (range 1.0-40.8; n = 33); 24 (72.7%) had baseline levels <20 ng/mL (consistent with deficiency). The mean levels increased to 43.6 +/-14.1 (range 18.2-69.7) at 4 months and remained relatively unchanged at month 7: 42.5 +/-12.1 ng/mL (range 18.9-67.2). The change in values between 1 and 4 months and 1 and 7 months was statistically significant (P </= .0001), and despite a decrease in dose per kilogram, values were not significantly different between months 4 and 7 (P = .66). Conclusions. Oral vitamin D(3) supplementation as an oil emulsion was associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months.

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References

    1. Kreiter S. The reemergence of vitamin D deficiency rickets-the need for vitamin D supplementation. In: Proceedings of the 6th International Meeting of the Academy of Breastfeeding Medicine; November 2001; Washington, DC, USA.
    1. Gartner L, Greer F. American Academy of Pediatrics. Section on Breastfeeding Medicine and Committee on Nutrition. Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake. Pediatrics. 2003;111:908–910. - PubMed
    1. Hollis BW, Wagner CL. Assessment of dietary vitamin D requirements during pregnancy and lactation. American Journal of Clinical Nutrition. 2004;79:717–726. - PubMed
    1. Hollis BW, Wagner CL. Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant. American Journal of Clinical Nutrition. 2004;80:1752S–1758S. - PubMed
    1. Wagner CL, Greer FR. American Academy of Pediatrics Section on, B., and American Academy of Pediatrics Committee on, N. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122(5):1142–1152. - PubMed