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. 2009 Nov;6(11):2725-39.
doi: 10.3390/ijerph6112725. Epub 2009 Oct 27.

A history of alcohol dependence increases the incidence and severity of postoperative cognitive dysfunction in cardiac surgical patients

Judith A Hudetz  1 , Kathleen M Patterson, Alison J Byrne, Zafar Iqbal, Sweeta D Gandhi, David C Warltier, Paul S Pagel
Affiliations

A history of alcohol dependence increases the incidence and severity of postoperative cognitive dysfunction in cardiac surgical patients

Judith A Hudetz et al. Int J Environ Res Public Health. 2009 Nov.

Abstract

Postoperative cognitive dysfunction (POCD) commonly occurs after cardiac surgery. We tested the hypothesis that a history of alcohol dependence is associated with an increased incidence and severity of POCD in male patients undergoing cardiac surgery using cardiopulmonary bypass. Recent verbal and nonverbal memory and executive functions were assessed before and one week after surgery in patients with or without a history of alcohol dependence. Cognitive function was significantly reduced after cardiac surgery in patients with versus without a history of alcohol dependence. The results suggest that a history of alcohol dependence increases the incidence and severity of POCD after cardiac surgery.

Keywords: alcohol dependence; cardiac surgery; cardiopulmonary bypass; neurocognitive function.

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