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. 2009 Dec;6(12):2934-49.
doi: 10.3390/ijerph6122934. Epub 2009 Nov 27.

Chronic stress and the development of early atherosclerosis: moderating effect of endothelial dysfunction and impaired arterial elasticity

Nadja Chumaeva  1 , Mirka Hintsanen, Niklas Ravaja, Markus Juonala, Olli T Raitakari, Liisa Keltikangas-Järvinen
Affiliations

Chronic stress and the development of early atherosclerosis: moderating effect of endothelial dysfunction and impaired arterial elasticity

Nadja Chumaeva et al. Int J Environ Res Public Health. 2009 Dec.

Abstract

This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly.

Keywords: atherosclerosis; carotid artery compliance; chronic stress; flow-mediated dilatation; intima-media thickness; vital exhaustion.

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References

    1. Juonala M. Cardiovascular risk factors and their associations with markers of subclinical atherosclerosis in young adults. The Cardiovascular Risk in Young Finns Study. Annales Universitatis Turkuensis. 2005:D645.
    1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801–809. - PubMed
    1. Rozanski A, Blumenthal JA, Davidson KW, Saab PG, Kubzansky L. The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. J. Am. Coll. Cardiol. 2005;45:637–651. - PubMed
    1. Corretti MC, Plotnick GD, Vogel RA. Technical aspects of evaluating brachial artery vasodilation using high-frequency ultrasound. Am. J. Physiol. 1995;268:H1397–1404. - PubMed
    1. Neunteufl T, Katzenschlager R, Hassan A, Klaar U, Schwarzacher S, Glogar D, Bauer P, Weidinger F. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis. 1997;129:111–118. - PubMed

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