Detection of R576 interleukin-4 receptor an allele gene, serum interleukin-4, and eosinophilic cationic protein in atopic dermatitis patients
- PMID: 20049266
- PMCID: PMC2800867
- DOI: 10.4103/0019-5154.48983
Detection of R576 interleukin-4 receptor an allele gene, serum interleukin-4, and eosinophilic cationic protein in atopic dermatitis patients
Abstract
Atopic dermatitis (AD) is a chronic pruritic skin disease. It results from a complex interplay between strong genetic and environmental factors. The aim of this work was to study some biochemical markers of the dermatosis. This included detection of R576 interleukin-4 receptor alpha allele gene. Twenty five patients with AD and 25 controls participated in this study.
Keywords: Allergy; asthma; atopy; cell; dermatitis; eosinophils; interleukin; mast; patients; proteins; remodeling.
Conflict of interest statement
Similar articles
-
The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.N Engl J Med. 1997 Dec 11;337(24):1720-5. doi: 10.1056/NEJM199712113372403. N Engl J Med. 1997. PMID: 9392697
-
Lack of association of atopy/asthma and the interleukin-4 receptor alpha gene in Japanese.Clin Exp Allergy. 1999 Feb;29(2):228-33. doi: 10.1046/j.1365-2222.1999.00458.x. Clin Exp Allergy. 1999. PMID: 10051727
-
Correlation of serum interleukin-31 with pruritus and blood eosinophil markers in children with atopic dermatitis.Allergy Asthma Proc. 2020 Jan 1;41(1):59-65. doi: 10.2500/aap.2020.41.190016. Allergy Asthma Proc. 2020. PMID: 31888784
-
[The role of eosinophilic granulocytes for the pathogenesis of atopic dermatitis /neurodermatitis. Eosinophilic products as markers of disease activity].Hautarzt. 1993 Jul;44(7):432-6. Hautarzt. 1993. PMID: 8365876 Review. German.
-
Interleukin-31 and interleukin-31 receptor: New therapeutic targets for atopic dermatitis.Exp Dermatol. 2018 Apr;27(4):327-331. doi: 10.1111/exd.13533. Exp Dermatol. 2018. PMID: 29524262 Review.
References
-
- Morar N, Willis-Owen SA, Moffatt MF, Cookson WO. The genetics of atopic dermatitis. J Allergy Clin Immunol. 2006;118:24–34. - PubMed
-
- Hahn EL, Bacharier LB. The atopic march: The pattern of allergic disease development in childhood. Immunol Allergy Clin North Am. 2005;25:231–46. - PubMed
-
- Leung DY, Bieber T. Atopic dermatitis. Lancet. 2003;361:151–60. - PubMed
-
- Novak N, Bieber T, Leung DY. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol. 2003;112:S128–39. - PubMed
-
- Chan LS, Robinson N, Xu L. Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis. J Invest Dermatol. 2001;117:977–83. - PubMed