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Review
. 2010 Apr;59(4):489-510.
doi: 10.1007/s00262-009-0804-6. Epub 2010 Jan 5.

Regulation of immunity and oncogenesis by the IRF transcription factor family

David Savitsky  1 , Tomohiko Tamura, Hideyuki Yanai, Tadatsugu Taniguchi
Affiliations
Review

Regulation of immunity and oncogenesis by the IRF transcription factor family

David Savitsky et al. Cancer Immunol Immunother. 2010 Apr.

Abstract

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.

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